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ANALYSIS REPORTFictional sample15.08.2026

Extent of Resection and Early Progression in Newly Diagnosed Supratentorial Glioblastoma: A Multicenter Retrospective Cohort (2016–2022)

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Key Points

1Multicenter retrospective cohort linking imaging-based extent of resection (EOR) to early progression-free survival in glioblastoma.
2Strengths include large n and multivariable adjustment; limitations include residual confounding, heterogeneous imaging protocols, and immortal time risks around re-resection documentation.

Major Issues

Methods: EOR is derived from local radiology reads without fully described blinding or central adjudication; inter-site measurement drift could bias category assignment.

Methods / Statistics: Immortal time and indication bias around second resections and salvage therapies are mentioned only briefly; the analytic timeline relative to progression ascertainment should be diagrammed.

Results: Missing MGMT data are handled via a missing indicator but the proportion missing per centre is not shown; residual confounding may concentrate in high-missing sites.

Discussion: Causal language occasionally overstates what observational HRs support; tighten wording and add E-values or quantitative bias analysis for the primary association.

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